ncbi.nlm.nih.gov about amniotic fluid embolism

Its histopathological diagnosis has been classically defined ( 2), that is, detection of fetal components in pulmonary vessels however, this is only applicable in fatal cases examined by autopsy and not in surviving cases. It is mainly characterized by the abrupt onset and rapid progression of maternal cardiopulmonary insufficiency, concomitant with Disseminated Intravascular Coagulation (DIC). The present study was performed to compare coagulopathy in the earlier stage between the amniotic fluid embolism patients diagnosed by Clark criteria (Clark group, n = 6), those by the Japanese criteria (Non-Clark group, n = 10), and peripartum controls and identify optimal clinical markers for earlier assessments of amniotic fluid embolism-related consumptive coagulopathy.Īmniotic fluid embolism (AFE) is a rare disease that is associated with high maternal and/or fetal morbidity and mortality rates ( 1). Amniotic fluid embolism cases with preceding consumptive coagulopathy may exist and are potential clinical targets for earlier assessments and interventions among amniotic fluid embolism cases fulfilling the Japanese, but not Clark criteria. The strict diagnostic criteria by Clark for amniotic fluid embolism include severe coagulopathy complicated by cardiopulmonary insufficiency, whereas the Japanese criteria also include postpartum hemorrhage or Disseminated Intravascular Coagulation in clinical practice. Amniotic fluid embolism is a rare disease that induces fatal coagulopathy however, due to its rarity, it has not yet been examined in detail.

Ncbi.nlm.nih.gov about amniotic fluid embolism